GLYCOFI SIGNS RESEARCH COLLABORATION WITH CENTOCOR, INC. TO EVALUATE THE EXPRESSION OF TWO PROTEINS

Lebanon, NH (April 13, 2005) – GlycoFi announced today that they initiated a collaboration with Centocor, Inc, to determine the feasibility of producing a Centocor protein using GlycoFi's proprietary yeast-based glycoprotein production technology. Under the agreement, Centocor has the option to use the GlycoFi-yeast based production system for future protein expression in return for milestone payments and royalties to GlycoFi. Financial details were not disclosed. In an on-going research study funded by Centocor, GlycoFi and Centocor are also evaluating the use of GlycoFi technology for the production of an undisclosed Centocor antibody. These two collaborations combine GlycoFi's unique expression technology for the production of human glycoproteins, including antibodies, with Centocor's expertise in the area of therapeutic proteins.

About GlycoFi's Technology

Sugars, or glycosylation, on the surface of a protein are known to influence critical pharmaceutical properties of therapeutic proteins and monoclonal antibodies. GlycoFi is the leader in the area of glycosylation engineering in living systems, and its patented, scaleable technology uniquely allows its partners to create specific human glycosylation variants of any therapeutic glycoprotein. For the first time, GlycoFi and its partners can systematically research the impact of a protein's glycovariants on its pharmaceutical properties, enabling the optimization of biological activity, receptor binding, serum half-life, and potency of the drug candidate, thereby reducing the overall development risk of the project.

About GlycoFi

GlycoFi, Inc. is a biotechnology company that leverages its pioneering protein production technology to develop, produce and commercialize Next Generation BiotherapeuticsT, alone and in partnership with other leading biopharmaceutical companies. For more information, please visit www.glycofi.com.

GlycoFi Contacts:

Michael Horvath
Chief Financial Officer
GlycoFi, Inc.
mhorvath@glycofi.com